Serotype-specific differences in short- and longer-term mortality following invasive pneumococcal disease.

ABSTRACT: Invasive pneumococcal disease (IPD), caused by infection with Streptococcus pneumoniae, has a substantial global burden. There are over 90 known serotypes of S. pneumoniae with a considerable body of evidence supporting serotype-specific mortality rates immediately following IPD. This is the first study to consider the association between serotype and longer-term mortality following IPD. Using enhanced surveillance data from the North East of England we assessed both the short-term (30-day) and longer-term (⩽7 years) independent adjusted associations between individual serotypes and mortality following IPD diagnosis using logistic regression and extended Cox proportional hazards models. Of the 1316 cases included in the analysis, 243 [18·5%, 95% confidence interval (CI) 16·4-20·7] died wit

SUBMITTER: Hughes GJ 

PROVIDER: S-EPMC4988273 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature