Physiological inputs regulate species-specific anatomy during embryogenesis and regeneration.

ABSTRACT: A key problem in evolutionary developmental biology is identifying the sources of instructive information that determine species-specific anatomical pattern. Understanding the inputs to large-scale morphology is also crucial for efforts to manipulate pattern formation in regenerative medicine and synthetic bioengineering. Recent studies have revealed a physiological system of communication among cells that regulates pattern during embryogenesis and regeneration in vertebrate and invertebrate models. Somatic tissues form networks using the same ion channels, electrical synapses, and neurotransmitter mechanisms exploited by the brain for information-processing. Experimental manipulation of these circuits was recently shown to override genome default patterning outcomes, resulting in head sha

SUBMITTER: Sullivan KG 

PROVIDER: S-EPMC4988443 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature