FGF13 modulates the gating properties of the cardiac sodium channel Na_v1.5 in an isoform-specific manner.

ABSTRACT: FGF13 (FHF2), the major fibroblast growth factor homologous factor (FHF) in rodent heart, directly binds to the C-terminus of the main cardiac sodium channel, Na_V1.5. Knockdown of FGF13 in cardiomyocytes induces slowed ventricular conduction by altering Na_V1.5 function. FGF13 has five splice variants, each of which possess the same core region and C terminus but differing in their respective N termini. Whether and how these alternatively spliced N termini impart isoform-specific regulation of Na_V1.5, however, has not been reported. Here, we exploited a heterologous expression to explore the specific modulatory effects of FGF13 splice variants FGF13S, FGF13U and FGF13YV on Na_V1.5 function. We found these three splice variants differentially modula

SUBMITTER: Yang J 

PROVIDER: S-EPMC4988462 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature