Novel prevention strategies for bacterial infections in cirrhosis.

ABSTRACT:

Introduction

Bacterial infections are a serious complication of cirrhosis, as they can lead to decompensation, multiple organ failure, and/or death. Preventing infections is therefore very relevant. Because gut bacterial translocation is their main pathogenic mechanism, prevention of infections is mostly based on the use of orally administered poorly absorbed antibiotics such as norfloxacin (selective intestinal decontamination). However, antibiotic prophylaxis leads to antibiotic resistance, limiting therapy and increasing morbidity and mortality. Prevention of bacterial infections in cirrhosis should therefore move away from antibiotics.

Areas covered

This review focuses on various potentially novel methods to prevent infections in cirrhosis focusing on non-antibiotic stra

SUBMITTER: Yan K 

PROVIDER: S-EPMC4988518 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature