Hyperdeactivation of the Default Mode Network in People With Schizophrenia When Focusing Attention in Space.

ABSTRACT: When studying selective attention in people with schizophrenia (PSZ), a counterintuitive but replicated finding has been that PSZ display larger performance benefits than healthy control subjects (HCS) by cues that predicts the location of a target stimulus relative to non-predictive cues. Possible explanations are that PSZ hyperfocus attention in response to predictive cues, or that an inability to maintain a broad attentional window impairs performance when the cue is non-predictive. Over-recruitment of regions involved in top-down focusing of spatial attention in response to predictive cues would support the former possibility, and an inappropriate recruitment of these regions in response to non-predictive cues the latter. We probed regions of the dorsal attention network while PSZ (N =

SUBMITTER: Hahn B 

PROVIDER: S-EPMC4988736 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature