Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure.

ABSTRACT:

Background

Alterations in intellectual ability and brain structure are important genetic markers for schizophrenia liability. How variations in these phenotypes interact with variance in schizophrenia liability due to genetic or environmental factors is an area of active investigation. Studying these genetic markers using a multivariate twin modeling approach can provide novel leads for (genetic) pathways of schizophrenia development.

Methods

In a sample of 70 twins discordant for schizophrenia and 130 healthy control twins, structural equation modeling was applied to quantify unique contributions of genetic and environmental factors on human brain structure (cortical thickness, cortical surface and global white matter fractional anisotropy [FA]), intellectual ability and sc

SUBMITTER: Bohlken MM 

PROVIDER: S-EPMC4988741 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature