Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial.

ABSTRACT:

Importance

The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain.

Objective

To evaluate the effects of intensive (<120 mm Hg) compared with standard (<140 mm Hg) SBP targets in persons aged 75 years or older with hypertension but without diabetes.

Design, setting, and participants

A multicenter, randomized clinical trial of patients aged 75 years or older who participated in the Systolic Blood Pressure Intervention Trial (SPRINT). Recruitment began on October 20, 2010, and follow-up ended on August 20, 2015.

Interventions

Participants were randomized to an SBP target of less than 120 mm Hg (intensive treatment group, n = 1317) or an SBP target of less than 140 mm Hg (standard treatment group, n 

SUBMITTER: Williamson JD 

PROVIDER: S-EPMC4988796 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature