Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study.

ABSTRACT:

Objective

The risk of developing adenocarcinoma in non-dysplastic Barrett's oesophagus is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers.

Methods

In a prospective cohort of patients with non-dysplastic Barrett's oesophagus, we evaluated six molecular markers: p16, p53, Her-2/neu, 20q, MYC and aneusomy by DNA fluorescence in situ hybridisation on brush cytology specimens. Primary study outcomes were the development of high-grade dysplasia or oesophageal adenocarcinoma. The most predictive clinical variables and markers were determined using Cox proportional-hazards models, receiver operating characteri

SUBMITTER: Timmer MR 

PROVIDER: S-EPMC4988941 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature