Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony.

ABSTRACT:

Background

Pulmonary transit time (PTT) is an indirect measure of preload and left ventricular function, which can be estimated using the indicator dilution theory by contrast-enhanced ultrasound (CEUS). In this study, we first assessed the accuracy of PTT-CEUS by comparing it with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Secondly, we tested the hypothesis that PTT-CEUS correlates with the severity of heart failure, assessed by MRI and N-terminal pro-B-type natriuretic peptide (NT-proBNP).

Methods and results

Twenty patients referred to our hospital for cardiac resynchronization therapy (CRT) were enrolled. DCE-MRI, CEUS, and NT-proBNP measurements were performed within an hour. Mean transit time (MTT) was obtained by estimating the time evolution of i

SUBMITTER: Herold IH 

PROVIDER: S-EPMC4989099 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature