Characterization of Somatically-Eliminated Genes During Development of the Sea Lamprey (Petromyzon marinus).

ABSTRACT: The sea lamprey (Petromyzon marinus) is a basal vertebrate that undergoes developmentally programmed genome rearrangements (PGRs) during early development. These events facilitate the elimination of ∼20% of the genome from the somatic cell lineage, resulting in distinct somatic and germline genomes. Thus far only a handful of germline-specific genes have been definitively identified within the estimated 500 Mb of DNA that is deleted during PGR, although a few thousand germline-specific genes are thought to exist. To improve our understanding of the evolutionary/developmental logic of PGR, we generated computational predictions to identify candidate germline-specific genes within a new transcriptomic dataset derived from adult germline and the early embryonic stages during which PGR occurs.

SUBMITTER: Bryant SA 

PROVIDER: S-EPMC4989109 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature