Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance.

ABSTRACT: Ohnologs -paralogous gene pairs generated by whole genome duplication- are enriched for dosage sensitive genes, that is, genes that have a phenotype due to copy number changes. Dosage sensitive genes frequently occur in the same metabolic pathway and in physically interacting proteins. Accumulating evidence reveals that functionally related genes tend to co-localize in the three-dimensional (3D) arrangement of chromosomes. We query whether the spatial distribution of ohnologs has implications for their dosage balance. We analyzed the colocalization frequency of ohnologs based on chromatin interaction datasets of seven human cell lines and found that ohnolog pairs exhibit higher spatial proximity in 3D nuclear organization than other paralog pairs and than randomly chosen ohnologs in the ge

SUBMITTER: Xie T 

PROVIDER: S-EPMC4989111 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature