The Evolution of REM Sleep Behavior Disorder in Early Parkinson Disease.

ABSTRACT:

Study objectives

To investigate the development of REM sleep behavior disorder (RBD) and REM sleep behavioral events (RBE) not yet fulfilling diagnostic criteria for RBD as markers for neurodegeneration in a cohort of Parkinson disease (PD) patients between their de novo baseline assessment and two-year follow-up in comparison to healthy controls (HC).

Methods

Clinically confirmed PD patients and HC with video-supported polysomnography (vPSG) data at baseline were re-investigated after two years. Diagnostic scoring for RBE and RBD was performed in both groups and related to baseline findings.

Results

One hundred thirteen PD patients and 102 healthy controls (HC) were included in the study. Within two years, the overall occurrence of behaviors during REM sleep in PD pa

SUBMITTER: Sixel-Doring F 

PROVIDER: S-EPMC4989262 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature