The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity.

ABSTRACT:

Background

MicroRNAs (miRNA) are varied in length, under 25 nucleotides, single-stranded noncoding RNA that regulate post-transcriptional gene expression via translational repression or mRNA degradation. Elevated levels of miRNAs can be detected in systemic circulation after tissue injury, suggesting that miRNAs are released following cellular damage. Because of their remarkable stability, ease of detection in biofluids, and tissue specific expression patterns, miRNAs have the potential to be specific biomarkers of organ injury. The identification of miRNA biomarkers requires a systematic approach: 1) determine the miRNA tissue expression profiles within a mammalian species via next generation sequencing; 2) identify enriched and/or specific miRNA expression within organs of toxico

SUBMITTER: Koenig EM 

PROVIDER: S-EPMC4989286 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature