RES-Scanner: a software package for genome-wide identification of RNA-editing sites.

ABSTRACT:

Background

High-throughput sequencing (HTS) provides a powerful solution for the genome-wide identification of RNA-editing sites. However, it remains a great challenge to distinguish RNA-editing sites from genetic variants and technical artifacts caused by sequencing or read-mapping errors.

Results

Here we present RES-Scanner, a flexible and efficient software package that detects and annotates RNA-editing sites using matching RNA-seq and DNA-seq data from the same individuals or samples. RES-Scanner allows the use of both raw HTS reads and pre-aligned reads in BAM format as inputs. When inputs are HTS reads, RES-Scanner can invoke the BWA mapper to align reads to the reference genome automatically. To rigorously identify potential false positives resulting from genetic vari

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4989487 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature