Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer.

ABSTRACT:

Background

This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development.

Results

To assess its role in ovarian cancer, microarray datasets (GSE14407, GSE30587, and GSE17260) in Gene Expression Omnibus (GEO) were utilized to assess the expression and clinical significance of C17orf91 in ovarian cancer. Next, loss-of-function studies were performed to establish the role of C17orf91 and the underlying mechanisms in ovarian cancer development. It was found that elevated expression of C17orf91 was observed in omental metastases when compared with matched primary ovarian tumors(GSE30587, P = 0.016). Moreover, Log Rank analysis revealed that increased expression of C17orf91 was associated with shorter progression

SUBMITTER: Li J 

PROVIDER: S-EPMC4989523 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature