Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage.

ABSTRACT: In vivo serial passage of non-pathogenic viruses has been shown to lead to increased viral virulence, and although the precise mechanism(s) are not clear, it is known that both host and viral factors are associated with increased pathogenicity. Under- or overnutrition leads to a decreased or dysregulated immune response and can increase viral mutant spectrum diversity and virulence. The objective of this study was to identify the role of viral mutant spectra dynamics and host immunocompetence in the development of pathogenicity during in vivo passage. Because the nutritional status of the host has been shown to affect the development of viral virulence, the diet of animal model reflected two extremes of diets which exist in the global population, malnutrition and obesity. Sen

SUBMITTER: Pena J 

PROVIDER: S-EPMC4989884 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature