Inference of Japanese encephalitis virus ecological and evolutionary dynamics from passive and active virus surveillance.

ABSTRACT: A comprehensive monitoring strategy is vital for tracking the spread of mosquito-borne Japanese encephalitis virus (JEV), the leading cause of viral encephalitis in Asia. Virus detection consists of passive surveillance of primarily humans and swine, and/or active surveillance in mosquitoes, which may be a valuable proxy in providing insights into ecological processes underlying the spread and persistence of JEV. However, it has not been well characterized whether passive surveillance alone can capture the circulating genetic diversity to make reasonable inferences. Here, we develop phylogenetic models to infer JEV host changes, spatial diffusion patterns, and evolutionary dynamics from data collected through active and passive surveillance. We evaluate the feasibility of using JEV sequenc

SUBMITTER: Pham TT 

PROVIDER: S-EPMC4989885 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature