A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure.

ABSTRACT:

Background

Prenatal exposure to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome.

Objective

The aim of the present study was to identify whether the expression of key genes, proteins, or both and their associated biological pathways are perturbed by compiling datasets from studies on prenatal arsenic exposure.

Methods

We compiled datasets from 12 studies that analyzed the relationship between prenatal iAs exposure and changes to the fetal epigenome (5-methyl cytosine), transcriptome (mRNA expression), and/or proteome (protein expression).

Findings

Across the 12 studies, a set of 845 unique genes was iden

SUBMITTER: Laine JE 

PROVIDER: S-EPMC4989910 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature