HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children.

ABSTRACT:

Objectives

Study of the effect of HIV on disease progression in heterogeneous severe malaria syndromes with imprecise diagnostic criteria has led to varying results. Characteristic retinopathy refines cerebral malaria (CM) diagnosis, enabling more precise exploration of the hypothesis that HIV decreases the cytokine response in CM, leading to higher parasite density and a poor outcome.

Methods

We retrospectively reviewed data on clinical progression and laboratory parameters in 877 retinopathy-positive CM cases admitted 1996-2011 (14.4% HIV-infected) to a large hospital in Malawi. Admission plasma levels of TNF, interleukin-10, and soluble intercellular adhesion molecule (sICAM-1) were measured by ELISA in 135 retinopathy-positive CM cases.

Results

HIV-infected CM cas

SUBMITTER: Mbale EW 

PROVIDER: S-EPMC4990000 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature