Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer.

ABSTRACT: Sporadic breast cancer develops through the accumulation of molecular abnormalities in normal breast tissue, resulting from exposure to estrogens and other carcinogens beginning at adolescence and continuing throughout life. These molecular changes may take a variety of forms, including numerical and structural chromosomal abnormalities, epigenetic changes, and gene expression alterations. To characterize these abnormalities, a review of the literature has been conducted to define the molecular changes in each of the above major genomic categories in normal breast tissue considered to be either at normal risk or at high risk for sporadic breast cancer. This review indicates that normal risk breast tissues (such as reduction mammoplasty) contain evidence of early breast carcinogenesis inclu

SUBMITTER: Danforth DN 

PROVIDER: S-EPMC4990153 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature