Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits.

ABSTRACT: Many signals of natural selection have been identified in the human genome. However, except for some single-locus mechanisms, most molecular processes generating these adaptation signals are still unknown. We developed an approach that integrates datasets related to genome-wide association studies (GWAS) with information about systems biology and genetic signatures of natural selection to identify evidence of polygenic adaptation. Specifically, we focused on five anthropometric measurements: body mass index (BMI), height, waist-to-hip ratio adjusted for BMI (WHR), and waist circumference adjusted for BMI (WC), and sex differences for WHR and WC. We performed an enrichment analysis for signals of natural selection in protein interaction networks associated with anthropometric traits in Euro

SUBMITTER: Polimanti R 

PROVIDER: S-EPMC4990182 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature