Regions of variable DNA methylation in human placenta associated with newborn neurobehavior.

ABSTRACT: The placenta regulates the in utero environment and functionally impacts fetal development. Candidate gene studies identified variation in placental DNA methylation is associated with newborn neurologic and behavioral outcomes including movement quality, lethargic behavior, attention, and arousal. We sought to identify novel regions of variable DNA methylation associated with newborn attention, lethargy, quality of movement, and arousal by performing an epigenome-wide association study in 335 infants from a US birth cohort. Methylation status was quantified using the Illumina HumanMethylation450 BeadChip array and associations to newborn outcomes assessed by the NICU Network Neurobehavioral Scales (NNNS) were identified while incorporating established bioinformatics algorithms to control f

SUBMITTER: Paquette AG 

PROVIDER: S-EPMC4990225 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature