CoQ10 in progressive supranuclear palsy: A randomized, placebo-controlled, double-blind trial.

ABSTRACT:

Objective

An investigator-initiated, multicenter, randomized, placebo-controlled, double-blind clinical trial to determine whether coenzyme Q10 (CoQ10) is safe, well tolerated, and effective in slowing functional decline in progressive supranuclear palsy (PSP).

Methods

Sixty-one participants received CoQ10 (2,400 mg/d) or placebo for up to 12 months. Progressive Supranuclear Palsy Rating Scale (PSPRS), Unified Parkinson's Disease Rating Scale, activities of daily living, Mini-Mental State Examination, the 39-item Parkinson's Disease Questionnaire, and 36-item Short Form Health Survey were monitored at baseline and months 3, 6, 9, and 12. The safety profile of CoQ10 was determined by adverse events, vital signs, and clinical laboratory values. Primary outcome measures were ch

SUBMITTER: Apetauerova D 

PROVIDER: S-EPMC4990260 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature