A Genomic Map of the Effects of Linked Selection in Drosophila.

ABSTRACT: Natural selection at one site shapes patterns of genetic variation at linked sites. Quantifying the effects of "linked selection" on levels of genetic diversity is key to making reliable inference about demography, building a null model in scans for targets of adaptation, and learning about the dynamics of natural selection. Here, we introduce the first method that jointly infers parameters of distinct modes of linked selection, notably background selection and selective sweeps, from genome-wide diversity data, functional annotations and genetic maps. The central idea is to calculate the probability that a neutral site is polymorphic given local annotations, substitution patterns, and recombination rates. Information is then combined across sites and samples using composite likelihood in o

SUBMITTER: Elyashiv E 

PROVIDER: S-EPMC4990265 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature