MiRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4.

ABSTRACT:

Background

In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage. These differences were closely associated with endoplasmic reticulum stress (ERS)-related proteins. Moreover, compared to the control group, the expression of transcription factor activating factor 4 (ATF4) was also found to be significantly different in the hypertensive patients with different degrees of vascular endothelial cells damage groups. These results were confirmed using gene prediction software, which showed synergistic effects between ATF4 and miR-1283. ATF4 is a key molecule in ERS. Three ERS pathways exist:protein kinase RNA-like ER kinase (PERK), activating transcription fac

SUBMITTER: He L 

PROVIDER: S-EPMC4990291 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature