Modification of Fear Memory by Pharmacological and Behavioural Interventions during Reconsolidation.

ABSTRACT:

Background

Dysfunctional fear responses play a central role in many mental disorders. New insights in learning and memory suggest that pharmacological and behavioural interventions during the reconsolidation of reactivated fear memories may increase the efficacy of therapeutic interventions. It has been proposed that interventions applied during reconsolidation may modify the original fear memory, and thus prevent the spontaneous recovery and reinstatement of the fear response.

Methods

We investigated whether pharmacological (propranolol) and behavioural (reappraisal, multisensory stimulation) interventions reduce fear memory, and prevent reinstatement of fear in comparison to a placebo control group. Eighty healthy female subjects underwent a differential fear conditioning

SUBMITTER: Thome J 

PROVIDER: S-EPMC4990323 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature