Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

ABSTRACT:

Rationale

The diabetes mellitus drug metformin is under investigation in cardiovascular disease, but the molecular mechanisms underlying possible benefits are poorly understood.

Objective

Here, we have studied anti-inflammatory effects of the drug and their relationship to antihyperglycemic properties.

Methods and results

In primary hepatocytes from healthy animals, metformin and the IKKβ (inhibitor of kappa B kinase) inhibitor BI605906 both inhibited tumor necrosis factor-α-dependent IκB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1β, and CXCL1/2 (C-X-C motif ligand 1/2). Metformin suppressed IKKα/β activation, an effect that could be separated from some metabolic actions, in that BI605906 did not mimic effects of metformin on l

SUBMITTER: Cameron AR 

PROVIDER: S-EPMC4990459 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature