Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis.

ABSTRACT:

Aim

To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis.

Methods

All association studies on COL1A1 and high myopia reported up to June 10, 2014 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were analyzed for single-nucleotide polymorphisms (SNPs) using fixed- and random- effects models according to between-study heterogeneity. Publication bias analyses were conducted by Egger's test.

Results

A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any signif

SUBMITTER: Gong B 

PROVIDER: S-EPMC4990585 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature