The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.

ABSTRACT:

Background

Our previous studies of Alzheimer's disease (AD) suggested that glutamine broadly improves cellular readiness to respond to stress and acts as a neuroprotectant both in vitro and in AD mouse models. We now expand our studies to a second neurodegenerative disease, ataxia-telangiectasia (A-T). Unlike AD, where clinically significant cognitive decline does not typically occur before age 65, A-T symptoms appear in early childhood and are caused exclusively by mutations in the ATM (A-T mutated) gene.

Results

Genetically ATM-deficient mice and wild type littermates were maintained with or without 4 % glutamine in their drinking water for several weeks. In ATM mutants, glutamine supplementation restored serum glutamine and glucose levels and reduced body weight loss. Los

SUBMITTER: Chen J 

PROVIDER: S-EPMC4991002 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature