Associations of genetic risk scores based on adult adiposity pathways with childhood growth and adiposity measures.

ABSTRACT:

Background

Results from genome-wide association studies (GWAS) identified many loci and biological pathways that influence adult body mass index (BMI). We aimed to identify if biological pathways related to adult BMI also affect infant growth and childhood adiposity measures.

Methods

We used data from a population-based prospective cohort study among 3,975 children with a mean age of 6 years. Genetic risk scores were constructed based on the 97 SNPs associated with adult BMI previously identified with GWAS and on 28 BMI related biological pathways based on subsets of these 97 SNPs. Outcomes were infant peak weight velocity, BMI at adiposity peak and age at adiposity peak, and childhood BMI, total fat mass percentage, android/gynoid fat ratio, and preperitoneal fat area. Anal

SUBMITTER: Monnereau C 

PROVIDER: S-EPMC4991119 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature