Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4991385 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Oncotarget 20160401 15
While it is well established that treatment of cancer patients with 5-Fluorouracil (5-FU) can result in immune suppression, the exact function of 5-FU in the modulation of immune cells has not been fully established. We found that low dose 5-FU selectively suppresses TH17 and TH1 cell differentiation without apparent effect on Treg, TH2, and significantly suppresses thymidylate synthase (TS) expression in TH17 and TH1 cells but has a lesser effect in tumor cells and macrophages. Interestingly, t ...[more]