MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) presents a major challenge in the clinic due to its lack of reliable prognostic markers and targeted therapies. Accumulating evidence strongly supports the notion that microRNAs (miRNAs) are involved in tumorigenesis and could serve as biomarkers for diagnostic purposes. To identify miRNAs that functionally suppress metastasis of TNBC, we employed a concerted approach with selecting miRNAs that display differential expression profiles from bioinformatic analyses of breast cancer patient databases and validating top candidates with functional assays using breast cancer cell lines and mouse models. We have found that miR-148a exhibits properties as a tumor suppressor as its expression is inversely correlated with the ability of both human and mouse breast

SUBMITTER: Xu X 

PROVIDER: S-EPMC4991462 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature