Development and validation of a prognostic nomogram based on the log odds of positive lymph nodes (LODDS) for breast cancer.

ABSTRACT:

Background

To evaluate the prognostic effect of log odds of positive lymph nodes (LODDS) and develop a nomogram for survival prediction in breast cancer patients at the time of surgery.

Results

LODDS was an independent risk factor for cancer-related death in breast cancer (hazard ratio: 1.582, 95%CI: 1.190-2.104). Menopausal status, tumor size, pathological lymph node staging, estrogen receptor status and human epidermal growth factor receptor-2 status were also included in the nomogram. The calibration plots indicated optimal agreement between the nomogram prediction and actual observation. Discrimination of nomogram was superior to the seventh edition TNM staging system [C-index: 0.745 vs. 0.721 (p = 0.03) in training cohort; 0.796 vs. 0.726 (p < 0.01) in validation cohort

SUBMITTER: Wen J 

PROVIDER: S-EPMC4991511 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature