TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.

ABSTRACT: Antibiotic administration can disrupt the intestinal microbiota and down-regulate innate immune defenses, compromising colonization resistance against orally acquired bacterial pathogens. Vancomycin-resistant Enterococcus faecium (VRE), a major cause of antibiotic-resistant infections in hospitalized patients, thrives in the intestine when colonization resistance is compromised, achieving extremely high densities that can lead to bloodstream invasion and sepsis. Viral infections, by mechanisms that remain incompletely defined, can stimulate resistance against invading bacterial pathogens. We report that murine norovirus infection correlates with reduced density of VRE in the intestinal tract of mice with antibiotic-induced loss of colonization resistance. Resiquimod (R848), a synthetic lig

SUBMITTER: Abt MC 

PROVIDER: S-EPMC4991618 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature