Inverse Stochastic Resonance in Cerebellar Purkinje Cells.

ABSTRACT: Purkinje neurons play an important role in cerebellar computation since their axons are the only projection from the cerebellar cortex to deeper cerebellar structures. They have complex internal dynamics, which allow them to fire spontaneously, display bistability, and also to be involved in network phenomena such as high frequency oscillations and travelling waves. Purkinje cells exhibit type II excitability, which can be revealed by a discontinuity in their f-I curves. We show that this excitability mechanism allows Purkinje cells to be efficiently inhibited by noise of a particular variance, a phenomenon known as inverse stochastic resonance (ISR). While ISR has been described in theoretical models of single neurons, here we provide the first experimental evidence for this effect. We fi

SUBMITTER: Buchin A 

PROVIDER: S-EPMC4991839 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature