Gestational age and birthweight for risk assessment of neurodevelopmental impairment or death in extremely preterm infants.

ABSTRACT:

Background

The risk of poor outcomes in preterm infants is primarily determined by birthweight (BW) and gestational age (GA). It is not known whether BW is a better outcome predictor than GA.

Objective

To test whether BW is better than GA (measured in days, rather than completed weeks) for prediction of neurodevelopmental impairment (NDI) and death.

Design/methods

Extremely preterm infants born at the National Institute of Child Health and Human Development (NICHD) Neonatal Research Network centres between 1998 and 2009 were studied. For the unadjusted analysis, the associations of GA (in days based on best obstetrical estimate) and BW (in grams) with NDI or death were compared using area under the curve (AUC). Adjusted analyses were performed using birth year, sex, r

SUBMITTER: Salas AA 

PROVIDER: S-EPMC4991950 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature