Increased long noncoding RNA SNHG20 predicts poor prognosis in colorectal cancer.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) have been suggested to be involved in the development and progression of malignancies. However, the investigation of small nucleolar RNA host gene 20 (SNHG20) on cancer progression remains unknown. The present study aims to explore the clinical significance of SNHG20 and its potential molecular mechanism in colorectal cancer (CRC).

Methods

Quantitative real-time PCR (qRT-PCR) was used to measure the SNHG20 expression in a total of 107 CRC tissues and CRC cell lines. Loss of function approach was employed to explore the biological roles of SNHG20 in vitro. Its potential molecular mechanism was further verified by western blotting and qRT-PCR.

Results

The results suggested that SNHG20 expression was significantly upregulated in C

SUBMITTER: Li C 

PROVIDER: S-EPMC4992210 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature