Identification of prohormones and pituitary neuropeptides in the African cichlid, Astatotilapia burtoni.

ABSTRACT:

Background

Cichlid fishes have evolved remarkably diverse reproductive, social, and feeding behaviors. Cell-to-cell signaling molecules, notably neuropeptides and peptide hormones, are known to regulate these behaviors across vertebrates. This class of signaling molecules derives from prohormone genes that have undergone multiple duplications and losses in fishes. Whether and how subfunctionalization, neofunctionalization, or losses of neuropeptides and peptide hormones have contributed to fish behavioral diversity is largely unknown. Information on fish prohormones has been limited and is complicated by the whole genome duplication of the teleost ancestor. We combined bioinformatics, mass spectrometry-enabled peptidomics, and molecular techniques to identify the suite of neuropept

SUBMITTER: Hu CK 

PROVIDER: S-EPMC4992253 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature