Association study of polymorphisms in the ABO gene with ischemic stroke in the Chinese population.

ABSTRACT:

Background

Ischemic stroke is the main cause of mortality and disability in older people worldwide. Recently epidemiological studies indicate that ischemic stroke is a complex disorder with a strong genetic component. Genome-wide association studies (GWAS) identified several single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD) and myocardial infarction (MI) locus in ABO gene. Our study examined the association between four variants in the ABO gene and the risk of ischemic stroke and its subtypes, large-artery atherosclerosis (LAA) and small-vessel diseases (SVD) in the Chinese population.

Methods

In this case-control study, we recruited 1897 subjects, including 979 healthy controls and 918 ischemic stroke patients (465 with LAA and 453 with SV

SUBMITTER: Ling X 

PROVIDER: S-EPMC4992279 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature