Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration: A New Paradigm in Cell Therapy.

ABSTRACT:

Rationale

The effects of c-kit(POS) cardiac progenitor cells (CPCs, and adult cell therapy in general) on left ventricular (LV) function have been regarded as modest or inconsistent.

Objective

To determine whether 3 CPC infusions have greater efficacy than 1 infusion.

Methods and results

Rats with a 30-day-old myocardial infarction received 1 or 3 CPC infusions into the LV cavity, 35 days apart. Compared with vehicle-treated rats, the single-dose group exhibited improved LV function after the first infusion (consisting of CPCs) but not after the second and third (vehicle). In contrast, in the multiple-dose group, regional and global LV function improved by a similar degree after each CPC infusion, resulting in greater cumulative effects. For example, the total increas

SUBMITTER: Tokita Y 

PROVIDER: S-EPMC4992406 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature