Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group.

ABSTRACT:

Objectives

Hepatic encephalopathy (HE) is challenging to identify in children with acute liver failure and was not a requirement for enrollment into the Pediatric Acute Liver Failure Study Group (PALFSG). The outcomes of PALFSG participants presenting with and without HE are presented.

Methods

PALFSG participants were classified based on daily assessment of HE during the first 7 days following study enrollment: group 1-never developed HE; group 2-no HE at enrollment with subsequent HE development; and group 3-HE at study enrollment. Clinical and biochemical parameters and outcomes of death, spontaneous recovery, or liver transplantation were compared between groups.

Results

Data from 769 PALFSG (54% boys; median age 4.2 years; range 0-17.9 years) participants were ana

SUBMITTER: Ng VL 

PROVIDER: S-EPMC4992416 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature