NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart.

ABSTRACT:

Rationale

NF2 (neurofibromin 2) is an established tumor suppressor that promotes apoptosis and inhibits growth in a variety of cell types, yet its function in cardiomyocytes remains largely unknown.

Objective

We sought to determine the role of NF2 in cardiomyocyte apoptosis and ischemia/reperfusion (I/R) injury in the heart.

Methods and results

We investigated the function of NF2 in isolated cardiomyocytes and mouse myocardium at baseline and in response to oxidative stress. NF2 was activated in cardiomyocytes subjected to H2O2 and in murine hearts subjected to I/R. Increased NF2 expression promoted the activation of Mst1 (mammalian sterile 20-like kinase 1) and the inhibition of Yap (Yes-associated protein), whereas knockdown of NF2 attenuated these responses after o

SUBMITTER: Matsuda T 

PROVIDER: S-EPMC4992450 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature