Expression of cell cycle-regulated genes and prostate cancer prognosis in a population-based cohort.

ABSTRACT:

Background

Prostate cancer (PCa) is clinically and biologically heterogeneous, making it difficult to predict at detection whether it will take an indolent or aggressive disease course. Cell cycle-regulated genes may be more highly expressed in actively dividing cells, with transcript levels reflecting tumor growth rate. Here, we evaluated expression of cell cycle genes in relation to PCa outcomes in a population-based cohort.

Methods

Gene expression data were generated from tumor tissues obtained at radical prostatectomy for 383 population-based patients (12.3-years average follow-up). The overall mean and individual transcript levels of 30 selected cell cycle genes was compared between patients with no evidence of recurrence (73%) and those who recurred (27%) or died (7%)

SUBMITTER: Rubicz R 

PROVIDER: S-EPMC4992473 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature