Association of Mbo I-RFLP at the Renin Locus (rs2368564) with Essential Hypertension.

ABSTRACT: Several lines of experimental and clinical evidence have alluded a pivotal role of renin in blood pressure homeostasis and therefore a relevance of molecular variants of the renin gene and essential hypertension have been speculated. This study was designed to evaluate the pattern, alliance and risk of renin Mbo I (10631A>G; rs2368564) polymorphism at the locus intron 9 for a possible role in modulating essential hypertension in adult population from Gujarat (India). A total of 257 consecutively enrolled essential hypertensive patients and 270 controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism method for the selected marker. Suitable descriptive statistics was used for different variables. Genotypic (x(2) 10.43, p 0.0054) and allelic (x(2) 11.4

SUBMITTER: Parchwani DN 

PROVIDER: S-EPMC4992485 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature