Direct in vivo evidence of activated macrophages in human osteoarthritis.

ABSTRACT:

Objective

Through binding to folate receptor-β (FR-β), the new (99m)Tc-EC20 (Etarfolatide) imaging technique detects activated but not resting macrophages in vivo. The goal of this study was to investigate macrophage-related inflammation in osteoarthritis (OA).

Methods

Twenty-five individuals (50 knees) with symptomatic OA of at least one knee underwent SPECT-CT imaging of both knees and planar imaging of the whole body after injection of Etarfolatide. Scans and knee radiographs were scored blinded to clinical information including knee and other joint site pain severity. Measures of association controlled for age, gender, body mass index (BMI) and employed repeated measures to adjust for correlation between knees.

Design

Activated macrophages were present in the majo

SUBMITTER: Kraus VB 

PROVIDER: S-EPMC4992586 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature