Preliminary differences in resting state MEG functional connectivity pre- and post-ketamine in major depressive disorder.

ABSTRACT: Functional neuroimaging techniques including magnetoencephalography (MEG) have demonstrated that the brain is organized into networks displaying correlated activity. Group connectivity differences between healthy controls and participants with major depressive disorder (MDD) can be detected using temporal independent components analysis (ICA) on beta-bandpass filtered Hilbert envelope MEG data. However, the response of these networks to treatment is unknown. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exerts rapid antidepressant effects. We obtained MEG recordings before and after open-label infusion of 0.5mg/kg ketamine in MDD subjects (N=13) and examined networks previously shown to differ between healthy individuals and those with MDD. Connectivity between the amygdala

SUBMITTER: Nugent AC 

PROVIDER: S-EPMC4992587 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature