NADPH Oxidase-Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses.

ABSTRACT: Originally recognized for their direct induced toxicity as a component of the innate immune response, reactive oxygen species (ROS) can profoundly modulate T cell adaptive immune responses. Efficient T cell activation requires: signal 1, consisting of an antigenic peptide-MHC complex binding with the TCR; signal 2, the interaction of costimulatory molecules on T cells and APCs; and signal 3, the generation of innate immune-derived ROS and proinflammatory cytokines. This third signal, in particular, has proven essential in generating productive and long-lasting immune responses. Our laboratory previously demonstrated profound Ag-specific hyporesponsiveness in the absence of NADPH oxidase-derived superoxide. To further examine the consequences of ROS deficiency on Ag-specific T cell response

SUBMITTER: Padgett LE 

PROVIDER: S-EPMC4992601 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature