YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis.

ABSTRACT: The germinal center (GC) reaction produces high-affinity Abs for a robust adaptive immune response. When dysregulated, the same processes cause GC B cells to become susceptible to lymphomagenesis. It is important to understand how the GC reaction is regulated. In this study, we show that transcription factor YY1 is required to maintain a robust GC reaction in mice. Selective ablation of YY1 significantly decreased in the frequency and number of GC B cells during the GC reaction. This decrease of GC B cells was accompanied by increased apoptosis in these cells. Furthermore, we found that loss of YY1 disrupted the balance between dark zones and light zones, leading to a preferential decrease in dark zone cells. Collectively, these results indicate that YY1 plays an important role in regulati

SUBMITTER: Trabucco SE 

PROVIDER: S-EPMC4992619 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature