Imaging of hypoxia in mouse atherosclerotic plaques with (64)Cu-ATSM.

ABSTRACT:

Introduction

Cardiovascular disease is the leading cause of death in the United States. The identification of vulnerable plaque at risk of rupture has been a major focus of research. Hypoxia has been identified as a potential factor in the formation of vulnerable plaque, and it is clear that decreased oxygen plays a role in the development of plaque angiogenesis leading to plaque destabilization. The purpose of this study is to demonstrate the feasibility of copper-64 labeled diacetyl-bis (N(4)-methylthiosemicarbazone) ((64)Cu-ATSM), a positron-emitting radiopharmaceutical taken up in low-oxygen-tension cells, for the identification of hypoxic and potentially unstable atherosclerotic plaque in a mouse model.

Methods

(64)Cu-ATSM PET was performed in 21 atherosclerotic apolipo

SUBMITTER: Nie X 

PROVIDER: S-EPMC4992634 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature