Divergent relationship of depression severity to social reward responses among patients with bipolar versus unipolar depression.

ABSTRACT: Neuroimaging studies of mood disorders demonstrate abnormalities in brain regions implicated in reward processing. However, there is a paucity of research investigating how social rewards affect reward circuit activity in these disorders. Here, we evaluated the relationship of both diagnostic category and dimensional depression severity to reward system function in bipolar and unipolar depression. In total, 86 adults were included, including 24 patients with bipolar depression, 24 patients with unipolar depression, and 38 healthy comparison subjects. Participants completed a social reward task during 3T BOLD fMRI. On average, diagnostic groups did not differ in activation to social reward. However, greater depression severity significantly correlated with reduced bilateral ventral striatum

SUBMITTER: Sharma A 

PROVIDER: S-EPMC4992640 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature